showed a trendp = 0.0547
Out of the remaining four miRNAs, three miRNAs, miR-423-3p, miR-320a, and miR-99a-5p were significantly differentially expressed between treatment-naive PCa patients and CRPC ( p = 7.3 × 10 −8 , 0.002 and 0.0186, respectively) ( Figure 2A ), while miR-193a-5p showed a trend without a statistically significant difference ( p = 0.0547).