Patients who have (or are carriers for) A1AT deficiency showed a trend towards more diverticula and, when diagnosed with acute diverticulitis, appeared to have a more severe course of diverticulitis compared to the patients with a normal type of A1AT.
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Alpha-1-antitrypsin deficiency (carrier) as possible risk factor for development of colonic diverticula. A multicentre prospective case-control study: the ALADDIN study.
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