RNA-seq-based profiling of extracellular vesicles in plasma reveals a potential role of miR-122-5p in asthma.

Next, we isolated EVs from additional plasma samples of the same subjects and 10 new subjects per group (Figure 2A ), and found a strong trend for an increase of miR‐122‐5p (FC = 1.84; P = .07) in severe asthma, and in all asthma subjects (FC = 1.96; P = .09) (Figure 2A ) by RT‐qPCR, confirming the sequencing results. miR‐191‐5p did not differ significantly among the groups, and miR‐3168 was not detectable by RT‐qPCR.

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