marginal significanceP < 5 × 10 −5
Of note, eleven of the 16 novel GWS loci exhibited consistent genome-wide marginal significance ( P < 5 × 10 −5 ) between ADHD and MDD.
Of note, eleven of the 16 novel GWS loci exhibited consistent genome-wide marginal significance ( P < 5 × 10 −5 ) between ADHD and MDD.
Among the five novel loci for ADHD in the MTAG analysis, the lead SNPs at two loci were of nominal association P value < 0.05 in the replication study, including rs10839264 at 11p11.12 ( P value = 0.0487), rs8083506 at18q12.3 ( P value = 0.0253); and rs6032660 at 20q13.12 is of marginal significance with P value = 0.0528 (Supplementary Table 14 ).
Our results indicated the highly significant enrichment of GWS loci of neuropsychiatric disorders in various aspects of neuronal activity.