Multi-Targeted Anticancer Activity of Imidazolate Phosphane Gold(I) Compounds by Inhibition of DHFR and TrxR in Breast Cancer Cells.

The results, reported in Figure 2 and Figure 1S , showed a trend of activity depending on the structure of the gold compounds; in fact, the most active compounds are the compounds 5 and 6 , while the compounds 1 , 2 and 3 , possessing the –COOH functional group on the PPh 3 moiety or the CH 2 OH group on the imidazole, did not show relevant cytotoxic activity.

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