CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9.

Cell Death Dis · 2021 · PMC7822921 · PMID 33483464

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Furthermore, the percentage of CDK9-positive cells was reduced in shCSN6 tumor samples and rescued in shCSN6/shUBR5 tumor samples, while the signal intensity of UBR5 showed a trend opposite that of CDK9 expression.

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