A significant difference in fibrosis was noticed between groups ( Figure 2 A,B) [ 20 ] with an increasing trend in fibrosis in CTRL/DOX when compared to CTRL/SAL.
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Creatine Alleviates Doxorubicin-Induced Liver Damage by Inhibiting Liver Fibrosis, Inflammation, Oxidative Stress, and Cellular Senescence.
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Furthermore, CTRL/DOX showed a trend toward a higher AST-to-ALT ratio than CTRL/SAL and a trend toward a decreased AST-to-ALT ratio in 4%/2% Cr/DOX was observed ( Figure 1 B, lower panel).