Interestingly, RNA sequencing data of FACS-purified pancreatic β-cells from four type 1 diabetes (T1D) and thirteen nondiabetic individuals showed a trend for a 60% decrease in TRMT10A mRNA expression in T1D β-cells [ 130 ].
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tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors.
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of FACS-purified pancreatic β-cells from four T1D patients and thirteen nondiabetic individuals showed no changes in JAZF1 or GARS1 expression and a nonsignificant trend for reduced DARS1 levels in T1D β-cells [ 130 ].