Ayurvedic Herbal Preparation Supplementation Does Not Improve Metabolic Health in Impaired Glucose Tolerance Subjects; Observations from a Randomised Placebo Controlled Trial.

The herbal intervention did not affect plasma glucose triglycerides, cholesterol, blood pressure or the augmentation index but showed a trend towards an increased insulin, HOMA-IR and postprandial insulin levels ( p = 0.054, p = 0.056 and p = 0.095 respectively).

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On the contrary, the borderline significant increase in fasting insulin, HOMA-index and 2 h glucose after 4-week herbal supplementation, may point towards an insulin desensitizing instead of a beneficial insulin sensitizing effect.

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