Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.

Likewise, combination of the mIgG1 or mIgG2b isotype of clone 9D9 with clone 80 induced proliferation or infiltration of proliferating cells that was numerically higher than in monotherapy controls, although the differences did not reach statistical significance.

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