The European Perspective on the Management of Acute Major Hemorrhage and Coagulopathy after Trauma: Summary of the 2019 Updated European Guideline.

8.36 ± 11.52 days, respectively), with an overall trend towards increased survival [ 23 ].

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Although the International Normalized Ratio (INR) detects the anticoagulant effect of vitamin K-dependent antagonists and neutralization can be achieved through emergency prothrombin complex concentrates (PCC) and oral vitamin K (R33/1A), the current clinical practice sees a significant trend towards the increased prescription of direct and non-vitamin K-dependent oral anticoagulants, e.g., apixaban, dabigatran, edoxaban, and rivaroxaban, for underlying cardiac and neurologic comorbidities.

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Recent studies have demonstrated a positive trend for survival and saving allogenic blood products in particular when the latter approach was followed [ 35 ].

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