In contrast, the correlation between CD4 + and CD8 + T cell responses was highly significant in aggregate (R = 0.6756; p = 1.70 × 10 −14 ; Figure 2 F) and was significant for each of the individual antigen comparisons ( Figures 2 G–2I).
A similar picture was noted in the case of CD8 + T cell reactivity ( Figures 7 C and 7D), where the CD8-E MP recapitulated the reactivity observed with the MPs of larger numbers of predicted peptides (CD8-A+B), with a strong trend (p = 0.0551 by Mann-Whitney) toward more reactivity than the EC class II pool.