Evaluation of Cardiac Circadian Rhythm Deconditioning Induced by 5-to-60 Days of Head-Down Bed Rest.

Diurnal and nocturnal QTc appeared prolonged after 60 days of HDT than after 5-day HDT (Day +3.7[1.7;6.4]%, Night +2.6[0.7;7.3]%), with a positive trend as HDT duration increases.

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However, the magnitude of post-HDT changes, as well as the difference between the last HDT day and R + 0, showed a trend to increase with increasing HDT duration, and 5/7 days were not sufficient for recovering after 60-day HDT.

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These changes in RR and QTc still persisted at R + 5/7, showing only a slight trend toward recovery.

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