"Holding-Cuddling" and Sucrose for Pain Relief During Venepuncture in Newborn Infants: A Randomized, Controlled Trial (CÂSA).

However, a positive trend in favor of the intervention “holding–cuddling” was observed in terms of a reduced pain score at 60 s, and, moreover, the rate of the high APN score at 60 s from venepuncture was significantly lower in the experimental group.

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The result reported did not reach statistical significance for the prespecified outcome measure, but it was significant for reducing the rate of the high pain score in the “holding–cuddling” group.

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