Large-scale systematic analysis of exposure to multiple cancer risk factors and the associations between exposure patterns and cancer incidence.

Of the nominally significant associations (0.00125 < P < 0.05), several reflect relationships that have also been reported previously, including associations between the ‘vigorous exercise’ factor and breast cancer 44 incidence for females and incidence of all cancers 45 for males (decreasing risks with higher scores), and between the ‘alcohol’ factor and bowel 46 and prostate cancer 47 incidence for males (increasing risks with higher scores).

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