A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models.

The 0.5 mg/kg dose exhibited a marginally significant increase in AUC glucose levels compared to controls (p = 0.054), while the 1, 2 and 6 mg/kg doses all evinced substantial increases in AUC values (p < 0.001); these effects were evident 15–30 minutes after the glucose challenge.

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Following the glucose challenge, the three highest doses of both drugs significantly increased glucose intolerance, with a strong trend for the 0.5 mg/kg dose of risperidone to do so, but not with the equivalent dose of paliperidone.

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