We therefore hypothesized albumin adsorption would have the greatest effect on the rate of Phos PS uptake by MΦ, since the highly significant reductions in Phos PS negative charge (Fig. 3d ) should decrease electrostatic repulsion with the negatively charged cell surface.
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Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets.
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The sentences
While albumin adsorption did modulate the MΦ uptake of neutral OH PS and MeO PS, a clear trend for electrostatic changes in mediating these effects was not established.