Sex-Associated Differences in Cytomegalovirus Prevention: Prophylactic Strategy is Potentially Associated With a Strong Kidney Function Impairment in Female Renal Transplant Patients.

As shown in Table 1 , significant ( p < 0.050) differences were found for MMF daily dose, CMV mismatch-based risk and therapy arm; the difference was highly significant ( p < 0.001) for the latter two factors; specifically among female patients a significant difference in body mass index and CMV mismatch was found, but not in therapy arm nor MMF daily dose (see Supplementary Table S3 ).

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However, the multi-parameter analysis ( Supplementary Table S2F ) could not confirm this tendency, as only a borderline significant association of prophylactic strategy group with rejection (−0.83 ± 0.51, p = 0.100) was observed; there was no evidence of an effect of sex, nor of the interaction with prevention strategy.

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Stratifying for CMV risk, a clear trend for lower incidence of CMV (re)activation was observed in the prophylactic strategy group; but not for CMV syndrome ( Supplementary Table S4B ).

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