Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development.

Although an overall trend of reduced locomotion was observed across all parameters, the difference between tdp1 −/− fish and their wild-type siblings in low speed count, medium speed, high speed duration and count, total distance traveled, and average speed did not reach statistical significance ( Fig. 3 and fig.

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However, qPCR validation showed a down-regulation in neil1 , both before and after CPT treatment, and a nonsignificant trend of sprtn down-regulation in tdp1 −/− embryos.

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