Old Cont‐11M mice showed longer latency to feed, suggesting age‐related anxiety, whereas cKO‐4M mice showed a trend of increased latency compared to Cont‐4M mice but not significantly different (Fig EV2I , latency to feeding, Cont‐4M 161.8 ± 22.2 s, Cont‐11M 322.3 ± 57.7 s, cKO‐4M 281.7 ± 55.0 s, P = 0.036, Kruskal–Wallis test).
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Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis.
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