Diet and companionship modulate pain via a serotonergic mechanism.

Sci Rep · 2021 · PMC7851147 · PMID 33526805

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showed a trendno p-value reported

Arginine supplementation showed a trend towards a decrease in VOC pain and a significant decrease in opioid use in children with SCD 113 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.