Role of adjunctive therapy with subantimicrobial doses of doxycycline in glycemic control (HbA1c) in patients with diabetes and endo-periodontal lesions to prevent sinus complications.

For the control group, we noted significant decreases for the bleeding index after 3 months (T1); however, this followed an increasing trend at 6 (T2) and 12 months from baseline (T3), approaching the initial values ( Fig. 1 ).

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The first reported was performed on 10 interventional studies, with a combined population of 456 patients; the authors identified a weighted average HbA1c reduction of 0.66% as a result of periodontal therapy (although this failed to reach statistical significance) ( 16 ).

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