Restrictive vs liberal red blood cell transfusion strategies in patients with acute myocardial infarction and anemia: Rationale and design of the REALITY trial.

15 , 16 However, a meta‐analysis of randomized trials in cardiac surgery showed a trend towards benefit of a liberal transfusion strategy, whereas in observational studies, transfusion (vs no transfusion) was associated with higher mortality. 31 In critical care patients, a randomized trial found that a liberal transfusion strategy (transfusion started when hemoglobin was <9 g/dL)

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