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Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host.

J Neuroinflammation · 2021 · PMC7852218 · PMID 33531028

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showed a trendno p-value reported
CpG ODN priming prolonged the course of pneumococcal meningitis, and CpG ODN-treated mice showed a trend towards lower mortality.

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