Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer's disease.

Transl Psychiatry · 2021 · PMC7854626 · PMID 33531457

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did not reach statistical significanceno p-value reported

4 , the effects of methylation levels on these three CSF biomarkers (Aβ42, p-tau/Aβ42, t-tau/Aβ42) seemed to be more obvious in APOE ɛ4 carriers, though these differences did not reach statistical significance in above interaction analysis probably because of the limited number of APOE ɛ4 carriers.

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an increasing trendno p-value reported

As predicted, frequency of positive APOE ε4 status showed an increasing trend in SCD subgroup (CN: 13.84%, SCD: 16.67%), although not statistically significant.

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