Managing Diabetic Macular Edema in Clinical Practice: Systematic Review and Meta-Analysis of Current Strategies and Treatment Options.

Clin Ophthalmol · 2021 · PMC7856351 · PMID 33551641

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.8000

boldest claim

The sentences

highly significantp<0.0001actually significant

After adjustment of effect size for potential publication bias using the trim-and-fill correction, missing studies were imputed in the funnel plot, resulting in lower, albeit still highly significant estimate of pooled mean difference (adjusted = +4.7 ETDRS letters; CI 95%: +3.7; +5.7; p<0.0001).

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a slight trendp=0.8not close (p > 0.1)

A slight trend towards better results with fixed regimen over PRN regimen (coefficient +0.4 ETDRS letters; CI 95%: −3.0; +3.9; p=0.8), and treat and extend regimen (coefficient +2.3 ETDRS letters; CI 95%: −3.2; +7.6; p=0.4) was observed.

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a decreasing trendno p-value reported

93 Our meta-regression also revealed a decreasing trend in visual acuity change with increasing age.

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showed a trendno p-value reported

Dexamethasone implant showed a trend for better results in observational studies over RCTs.

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