Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro.

Biol Open · 2021 · PMC7860133 · PMID 32878879

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trending towards significanceno p-value reported

CD38 had an insignificant log 2 FC of -0.53 in cryopreserved cells ( N =6, n =3, P =0.24) and −0.48 ( N =6, n =3, P =0.069) in the newly generated cell line; however, we do not believe that this is necessarily a reason to completely disregard the involvement of CD38 in the altered APP metabolism observed, as it is trending towards significance in the newly generated cell line.

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<i>Adenosine triphosphate binding cassette subfamily C member 1</i> (<i>ABCC1</i>) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, <i>in vitro</i>.

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