In the first experiment, transduction of L3s with the shRNAmirs had no effect on ache-b transcripts in adult worms compared to wild type controls, whereas a reduction of ~20% (mean log2 ± SEM = -0.3 ± 0.08) following transduction of L3s with the lhp construct did not reach statistical significance at p<0.05 ( S2A Fig ).
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Lentiviral transduction facilitates RNA interference in the nematode parasite Nippostrongylus brasiliensis.
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