Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques.

Mean sEPSC frequencies in CA1 neurons were decreased in APP/PS1 mice compared to WT littermates, although this effect did not reach statistical significance ( Figure 6 D; WT: 1.07 ± 0.14 Hz (n = 12/N = 4); APP/PS1: 0.76 ± 0.09 Hz (n = 7/N = 3), Mann–Whitney U-test U = 61.0, p = 0.108), whereas the sEPSC inter-event interval distribution differed beween the two groups (IEIs, Figure 6 D; Kolmogorov–Smirnov test D = 0.0518; p = 0.0046).

also in 111,027 other papers