Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer.

Sci Rep · 2021 · PMC7873274 · PMID 33564016

Europe PMC DOI

hedged sentences

0.0090

closest p · 0.2× alpha

0.1100

boldest claim

The sentences

highly significantP = 0.009actually significant

Most GMP positive tumors (9 of 14 cases) had HER2-enriched or basal-like phenotypes, and the association with the basal-like group was highly significant when compared with the other subgroups (OR 5.4, P = 0.009).

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did not reach statistical significanceP = 0.11not close (p > 0.1)

When dichotomizing MVD and pMVD vessel numbers at week 12, by baseline median values, only 1 of 38 patients in the bevacizumab-arm, and 6 of 39 patients in the chemotherapy only-arm, had high MVD, although this did not reach statistical significance (OR 6.7, CI 0.8–58.8, P = 0.11, Fisher’s exact test).

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borderline significantno p-value reported

All statistical tests were two-sided, and statistical significance was assessed at 5% level, and P values between 5 and 10% were regarded as borderline significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.