Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice.

Upon examination of T cells expressing a combination of TNFa and IFNg, we found that mice from lines with superior early virologic control (low d2 titer) had an increased frequency and number of CD8 T cells that were TNFa-IFNg+ ( Figs 3D and S1 ) and a decreased frequency that were TNFa+IFNg- ( Fig 3E ), though the latter did not reach statistical significance after adjusting for multiple comparisons.

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