Interestingly, both in the case of H55K and H55A, the flipping rates δ were significantly decreased (H55K: p = 0.002, n = 4, H55A: n = 4, p = 0.0001, WT: n = 7), and for H55E, the change of this rate did not reach statistical significance.
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α<sub>1</sub> Subunit Histidine 55 at the Interface between Extracellular and Transmembrane Domains Affects Preactivation and Desensitization of the GABA<sub>A</sub> Receptor.
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