SAMP8 hippocampus showed increased expression of Chil1 at old age, although the increase of Trem2 did not reach statistical significance compared to SAMR1. sEOAD patients showed also a borderline significance in the increase of TREM2 .
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Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer's Disease Traits.
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The sentences
This increase was of borderline significance for sEOAD but highly significant for ADAD.