In vitro model of perimenopausal depression implicates steroid metabolic and proinflammatory genes.

Sets of DEGs between treatments were partially overlapping and we observed that the intersection of genes that differed between PMD and controls regardless of LCL treatment was highly significant (probability density p<6.49e −41 , Figure 2A ).

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The significant difference in IGLL5 did not reoccur in the qRT-PCR independent cohort, but showed a trend consistent with RNA-seq observations, with approximately 10% of women with PMD showing strikingly higher (>12-fold) IGLL5 compared to controls after E2-withdrawal (Figure S6C, D).

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