A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.

Men with the C allele of the m.1382A>C polymorphism showed a trend for higher risk for T2D regardless of physical activity status measured by accelerometer (C allele, 13.1%; A allele, 10.8%; p = 0.196, Supplementary Table 1 top), however, when assessing potential contributors to T2D risk, the degree of physical activity, measured by accelerometer, and expressed as moderate- to vigorous-intensity physical activity (MVPA), correlated with lower risk for T2D in men with the C allele (MVPA beta = 0.023; p = 0.035; Supplementary Tables 4 , 5 ).

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