Of these, six miRNAs were significantly upregulated after UNC1999 treatment (i.e., miR-130a-3p, miR-134-5p, miR-192-5p, miR-4429, miR-223-3p and miR-320c) and four miRNAs showed a trend towards upregulation (i.e., miR-494-3p, miR-23a-3p, miR-21-5p and miR-27a-3p) (Supplementary Fig. 6h–v ).
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A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma.
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