As can be seen in Figure 3G , although Nkx2.2 cre , ROSA +/hM4Di animals showed a trend to increased Euclidean distance, it did not meet our threshold of significance.
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Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non-cell autonomous developmental mechanisms.
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The sentences
This trend is represented as a decrease in percent of positively expressed ISLET cells labeled with DAPI in the mutants which approaches statistical significance by E12.5 (Supporting Table S9 – Online Resource 1).