A nonsignificant trend toward higher glucagon content in the small intestine was observed in αTSC2 KO mice ( Supplementary Fig. 2 F ).
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Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.
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Control mice showed a trend of increased glucagon levels 7 days after STZ, but αTSC2 KO mice remained hyperglucagonemic before and after STZ administration ( Fig. 7 B ).