Genetic variants and physical activity interact to affect bone density in Hispanic children.

Polygenic risk score (PRS) computation SNPs of PRS include: 1) SNPs that are statistically significant or nominally significant per GWAS threshold ( p < 1.0 × 10 − 7 and p < 1.0 × 10 − 6 , respectively) and exome sequencing analysis ( p < 9.2 × 10 − 7 and p < 9.2 × 10 − 6 , respectively) [ 14 ]; 2) Index SNPs or Proxy SNPs in 1 Mb region that were statistically significantly and nominally significantly associated with bone health ( p < p value threshold and p < 0.05, respectively).

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