Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans.

The concordance of the aging‐related proteins was highly significant ( p from Fisher exact test 4E‐5). 2.1.3 Functional annotation of the centenarian signature Annotation of the results using the 50 Hallmark pathways (Liberzon et al., 2015 ) ( http://software.broadinstitute.org/gsea/msigdb/genesets.jsp?collection=H ) identified 12 pathways important to the immune system and the cell cycle with nominal level of statistical significance (20% FDR: Figure 1b ).

also in 132,142 other papers

We identified 237 aptamers that were nominally differentially expressed between centenarians' offspring and controls (after adjusting for sex and sample age) but did not reach statistical significance after correction for multiple testing (Table S1e ).

also in 111,027 other papers