α-ketoglutarate delays age-related fertility decline in mammals.

α‐KG treatment slightly increased the ratio of normal MII oocytes to total oocytes but failed to reach statistical significance (Figure 4c ) ( p > 0.05). 2.5. α‐KG reduces the decline of primary and growing follicles in advanced age mice The ovaries of young (8 weeks old), 14‐month‐old control and 14 months old with 10 mM α‐KG treated mice were collected for continuously sectioning, and the numbers of different grade follicles were recorded.

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Statistical analyses were performed using the univariate analysis of chi‐square test or variance (ANOVA) followed by the Student t test with the aid of SPSS 20.0 statistical software, p < 0.05 was considered significant, and p < 0.01 was considered highly significant.

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