Tumor immunogenomic signatures improve a prognostic model of melanoma survival.

J Transl Med · 2021 · PMC7888085 · PMID 33596955

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1650

boldest claim

The sentences

highly significantp = 1.94E−09actually significant

This important analysis showed that the same Cox model of TMB/IFNγRes/MacReg is highly significant in the association analysis of survival of patients with advanced disease (log-rank p = 1.94E−09) (Additional file 1 : Table S6).

also in 132,142 other papers

did not reach statistical significancep = 0.165not close (p > 0.1)

This threshold was found to be optimal in the bootstrap analysis and was moved forward to the validation 1 phase: while low NB showed comparable effect to low TMB (low NB = 3.6 years, high NB = 9.8 years) (Additional file 1 : Figure S1B and E, Table 1 , Additional file 1 : Table S3) the association with OS did not reach statistical significance in validation 1 cohort (p = 0.165, HR = 1.78, 95% CI 0.79–4.01).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.