Genetically Predicted C-Reactive Protein Associated With Postmenopausal Breast Cancer Risk: Interrelation With Estrogen and Cancer Molecular Subtypes Using Mendelian Randomization.

In our MR study, only longer-term users of E + P (≥5 years) had CRP-increased risk for breast cancer, implying an effect of long-term cumulative exposure to synthetic progestin that interacts with inflammation, although this association did not reach statistical significance; that result warrants future studies with a larger population for more definitive results.

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