Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder.

PLoS Genet · 2021 · PMC7888619 · PMID 33539344

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 1.4E-25actually significant

We confirmed a highly significant over-transmission of ASD PRS from parents to probands in multiple datasets (p = 1.4E-25 in the meta-analysis), including the SPARK cohort which has not been previously analyzed (p = 1.0E-11; S1 Fig ).

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nominally significantP<0.05actually significant

S4 Table Gene set enrichment results based on nominally significant TWAS genes (P<0.05).

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