Caffeine may disrupt the impact of real-time drowsiness on cognitive performance: a double-blind, placebo-controlled small-sample study.

The same interaction was nearing significance for procedural decision performance ( t (72.18) = − 1.82, p = 0.07 for the lapses in the two-choice reaction task—see Fig. 3 ) and vigilance performance (PVT lapses: t (93.13) = − 1.76 , p = 0.08, see Fig. 4 ) but disappeared almost completely for Simple Reaction times ( t (90.67) = − 0.79, p = 0.434).

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The differences between the caffeine and placebo groups did not reach statistical significance even after 19 h of continuous wakefulness and during circadian troughs.

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