Selective deletion of the receptor for CSF1, c-fms, in osteoclasts results in a high bone mass phenotype, smaller osteoclasts in vivo and an impaired response to an anabolic PTH regimen.

The difference in the response to CSF1 based on genotype was highly significant (p < 0.001).

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The changes in absolute BMD values mirrored the findings when BMD was analyzed as percent change, but because of the variability in absolute BMD values, the change in absolute BMD at the spine did not reach statistical significance.

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