Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting.

The correlation between the ranking of amino acids of Figure 4 A and the one in Figure 5 E was highly significant (ρ = 0.81; p = 1.03 × 10 −5 ), despite the limited number of epitopes with available X-ray structures used to estimate amino acid frequencies in Figure 5 E.

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The ratio of binding affinity between the mutant and the WT peptides did not reach statistical significance either, and the trend was mainly driven by mutations observed at anchor positions, where the ratio correlates most with the actual binding affinity ( Figures S1 D and S1E).

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