Cortical axonal loss is associated with both gray matter demyelination and white matter tract pathology in progressive multiple sclerosis: Evidence from a combined MRI-histopathology study.

Mult Scler · 2021 · PMC7897796 · PMID 32390507

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Associations between WM damage and axonal loss in normal-appearing cortical GM In MS patients, AD NAWM and MD NAWM showed negative associations with axonal density of connected NAGM ( p = 0.04 and p = 0.049, respectively), while RD NAWM showed a trend ( p = 0.06) and FA NAWM was not associated ( Figure 3(a) and ( b ); Table 4 ).

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