Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in Mice.

Consistent with the restoration of goblet cells and improvement to the colonic epithelium after 7 weeks in CTα IKO mice, mRNA levels of the goblet cell marker Muc2 were comparable between groups ( Figure 4 F ), while Tff3 levels tended to be modestly lower in CTα IKO mice but did not reach statistical significance ( P = .055).

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