Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study.

In line with this finding, signet ring cell differentiation was significantly more frequent in patients below 40 years of age (14.8% vs 3.3% of patients ≥ 50 years, P = 0.015, Figure 1 ) even though this did not reach statistical significance in the cohort < 50 years compared to patients over 50 years (8.7% vs 3.3%, P = 0.12) (Table 2 ).

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